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Registration Dossier
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EC number: 202-597-5 | CAS number: 97-63-2
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 370.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Modified dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 267 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10.8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Modified dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The long-term DNELs for EMA for all relevant routes and groups were derived by interpolation between the respective DNELs for MMA and n-BMA, weighed by the difference in molecular weight.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 76 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Modified dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 189.8 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
- Modified dose descriptor starting point:
- other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The long-term DNELs for EMA for all relevant routes and groups were derived by interpolation between the respective DNELs for MMA and n-BMA, weighed by the difference in molecular weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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