Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
370.5 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Modified dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
267 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
10.8 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Modified dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
sensitisation (skin)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

The long-term DNELs for EMA for all relevant routes and groups were derived by interpolation between the respective DNELs for MMA and n-BMA, weighed by the difference in molecular weight.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
76 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Modified dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
189.8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
6.5 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Modified dose descriptor starting point:
other: Interpolation between the respective DNELs of the closest analogous substances in the category, i.e. MMA and nBMA.
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
sensitisation (skin)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
sensitisation (skin)

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

The long-term DNELs for EMA for all relevant routes and groups were derived by interpolation between the respective DNELs for MMA and n-BMA, weighed by the difference in molecular weight.