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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

The bioaccumulation potential of 4-Hydroxy-TEMPO was estimated by calculation of the BFC with EPIWIN software using BCFBAF v1.5. A BCF value of 3.162 L/kg wwt and a log Kow of 0.55 was calculated. Thus the test item can be considered that is unlikely to have potential for bioaccumulation.

Key value for chemical safety assessment

BCF (aquatic species):
3.162 L/kg ww

Additional information

The performance of a test for bioaccumulation in aquatic species, preferably fish, is scientifically unjustified. REACH Regulation (EC) No 1907/2006, Annex IX, Sect. 9.3.2, Col. 2, states as follows: “9.3.2 The study need not be conducted if:

- the substance has a low potential for bioaccumulation (for instance a log Kow <= 3) and/or a low potential to cross biological membranes, or

- direct and indirect exposure of the aquatic environment is unlikely. ”

4-Hydroxy-TEMPO was considered to have no bioaccumulation potential. Using EPIWIN 4.1 a BCF of 3.162 L/Kg wwt and a log Kow of 0.56 was calculated indicating no potential for bioaccumulation.