Reaction mass of 3-isopropyl-6-methylenecyclohexene and (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene and (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexene

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Results from a review

Cross-reference

Reason / purpose for cross-reference:

read-across: supporting information

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2008

Materials and methods

Type of sensitisation studied:

skin

Study type:

study with volunteers

Principles of method if other than guideline:

Human repeated insult patch test

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

(R)-p-mentha-1,8-diene

EC Number:

227-813-5

EC Name:

(R)-p-mentha-1,8-diene

Cas Number:

5989-27-5

Molecular formula:

C10H16

IUPAC Name:

(4R)-isopropenyl-1-methylcyclohexene

Test material form:

liquid

Method

Type of population:

not specified

Controls:

No data

Route of administration:

dermal

Results and discussion

Results of examinations:

No data

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Conclusions:

In a human repeated insult patch test, the NOEL (highest concentration tested with no sensitization in human) was 10000 µg/cm².

Executive summary:

The NOEL (highest concentration tested with no sensitization in human), based on Human Repeated Insult Patch Test, was 10000 µg/cm². This value is very close to LLNA weighed mean EC3 values from five LLNA studies (=10075 µg/cm²).