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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well reported study but with some restrictions, no information about acclimatisation and housing

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulphonyl chloride
EC Number:
202-636-6
EC Name:
Benzenesulphonyl chloride
Cas Number:
98-09-9
Molecular formula:
C6H5ClO2S
IUPAC Name:
benzenesulfonyl chloride

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: own breed
- Weight at study initiation: 80-100 g (average : 89g)
- Fasting period before study: 16h
- Housing: plastic cages with wood shavings
- Diet (e.g. ad libitum): ALTROMIN 1324 der Firma Altrogge in Lage/Lippe ad libitum
- Water (e.g. ad libitum): tap water ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Sesam oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 25%
Doses:
1250, 1600, 2000, 2500, 3200, 5000 mg/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes but only macroscopic
Statistics:
The LC50 were calculated by Probitanalyse and the confidence limits with Cavalli-Sforza.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
1 860 mg/kg bw
95% CL:
1 683 - 2 056
Mortality:
Before dying the rats had equilibration problems and died in prone position.
Clinical signs:
other: Irritation of the stomach and intestinal mucosa

Applicant's summary and conclusion