Registration Dossier
Registration Dossier
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EC number: 202-636-6 | CAS number: 98-09-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well reported study but with some restrictions, no information about acclimatisation and housing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulphonyl chloride
- EC Number:
- 202-636-6
- EC Name:
- Benzenesulphonyl chloride
- Cas Number:
- 98-09-9
- Molecular formula:
- C6H5ClO2S
- IUPAC Name:
- benzenesulfonyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breed
- Weight at study initiation: 80-100 g (average : 89g)
- Fasting period before study: 16h
- Housing: plastic cages with wood shavings
- Diet (e.g. ad libitum): ALTROMIN 1324 der Firma Altrogge in Lage/Lippe ad libitum
- Water (e.g. ad libitum): tap water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesam oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% - Doses:
- 1250, 1600, 2000, 2500, 3200, 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes but only macroscopic - Statistics:
- The LC50 were calculated by Probitanalyse and the confidence limits with Cavalli-Sforza.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 860 mg/kg bw
- 95% CL:
- 1 683 - 2 056
- Mortality:
- Before dying the rats had equilibration problems and died in prone position.
- Clinical signs:
- other: Irritation of the stomach and intestinal mucosa
Applicant's summary and conclusion
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