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EC number: 202-636-6 | CAS number: 98-09-9
Environmental fate & pathways
Hydrolysis
Currently viewing:
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study according OECD 111 and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2110 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Benzenesulphonyl chloride
- EC Number:
- 202-636-6
- EC Name:
- Benzenesulphonyl chloride
- Cas Number:
- 98-09-9
- Molecular formula:
- C6H5ClO2S
- IUPAC Name:
- benzenesulfonyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Benzenesulphonyl chloride (provichem 0203)
- Analytical purity: 99.95%
-Molecular weight: 176.62
- Lot/batch No.: 200911040020
-Production date: 04/11/2009
-Shelf life: 1 year
- Storage condition of test material: Ambient room temperature 20-30°C
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: hydrolysis samples were collected from each pH after the test solution was placed into the test vessels (0h) and at 2h, 5h, 1d, 5d.
- Sampling method:At each sampling interval for each buffer test system, duplicate samples were taken and analyzed by HPLC.
- Sampling intervals/times for pH measurements:The pH of the buffer solutions were measured after preparation and sterile filtration. The pH was also documented after sample fortification of pH 4, 7 and 9 buffer test solution on Day 0 and Day 5.
- Sampling intervals/times for sterility check:Sterility was determined at Day 0 for sterile pH 4, 7 and 9 buffer test systems and at day 5 for pH 4, 7 and 9 buffer test system. Sterility was checked by serial dilution plate technique. Agar plates (Nutrient agar for bacteria) were used to determine sterility of buffer test systems.
-Samples were analysed on the sampling day - Buffers:
- - pH: 4, 7, 9
- Type and final molarity of buffer,Composition of buffer:
pH4: 0.01 M: 410 mL of 0.01 M acetic acid solution with 90 mL of 0.01 M sodium acetate solution
pH7: 0.02M: 195 mL of 0.02M sodium phosphate (monobasic) and 305 mL of 0.02M sodium phosphate (dibasic) to a 1000mL flask
pH9: 0.5M boric acid: - Details on test conditions:
TEST MEDIUM
- Volume used/treatment: nominal test item concentration was 5 mg/L
- Kind and purity of water: Milli-Q-water
- Preparation of test medium: dilution of stock solution with filter-sterilized buffer solution to obtain 5 mg/L
Duration of testopen allclose all
- Duration:
- 0 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 5.11 mg/L
- Duration:
- 0 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 5.12 mg/L
- Duration:
- 0 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 5.25 mg/L
- Number of replicates:
- 2 replicates per test system
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- The base 10 logarithm of the concentration of BSC was plotted as a function of time and the line fit to the data was determined using Excel.
Results and discussion
- Preliminary study:
- Analysis of pH 4 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis.
Analysis of pH 7 buffer solution at Day 5 showed >90% of the recovered test item compared to the 0 Hour analysis.
Analysis of pH 9 buffer solution showed >90% of the recovered test item compared to the 0 Hour analysis.
Benzenesulphonyl chloride (Provichem 0203) was hydrolytically stable at pH 4, pH 7 and pH 9 based on the preliminary result. So definitive study was not conducted.
Total recovery of test substance (in %)open allclose all
- % Recovery:
- > 90
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
Applicant's summary and conclusion
- Conclusions:
- This study demonstrated that Benzenesulphonyl chloride (Provichem 0203) was hydrolytically stable at pH 4, 7 and 9. Based on the results of this study, hydrolysis will not be a route of degradation of Benzenesulphonyl chloride (Provichem 0203) in the environment.
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