Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publications: Review articles related to inhalation toxicity of isocyanates, also 4,4'-methylenedicyclohexyl diisocyanate

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives
Author:
Vandenplas O
Year:
1993
Bibliographic source:
British Journal of Industrial Medicine 50, 213-228
Reference Type:
review article or handbook
Title:
Respiratory effects of inhaled isocyanates
Author:
Karol MH
Year:
1986
Bibliographic source:
Critical Reviews in Toxicology 16, 4, 349-379

Materials and methods

Test material

Constituent 1
Reference substance name:
Reference substance 001
Cas Number:
57378-68-4
Details on test material:
Isocyanates in general; also 4,4'-methylenedicyclohexyl diisocyanate

Results and discussion

Applicant's summary and conclusion