2-chlorotoluene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: careful observations reported but LD50 value was not reached

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

5 rats/sex, hairs removed from the trunk, chemical applied to this prepared area of the skin, single application of 1 ml/kg for 24 hours, during exposure covered with plaster backed with aluminium foil

GLP compliance:

no

Test type:

other: single dose: 1ml/kg bw for 24 hours

Test material

Test material information

1

Reference substance name:

2-chlorotoluene

EC Number:

202-424-3

EC Name:

2-chlorotoluene

Cas Number:

95-49-8

Molecular formula:

C7H7Cl

IUPAC Name:

1-chloro-2-methylbenzene

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

1 ml/kg bw = 1.08 g/cm³ (density = 1.08 g/cm according LXS MSDS)

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 080 mg/kg bw

Any other information on results incl. tables

Immediately after the application, the animals showed excitation  obviously induced by pain and lasting for up to 2 h, within 24 h difficulty of breathing occurred; the general condition of the animals was reduced up to 8 d after administration of the test  substance; no deaths occurred; after 24 h, the treated areas of skin showed no signs of irritation

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

To 5 rats/sex the hairs was removed from the trunk and the chemical applied to this prepared area of the skin. During the single application of 1 ml/kg for 24 hours, the skin was covered with plaster backed with aluminium foil.

Result: LD50 > 1.08 g/kg bw (rat); no death occured

Executive summary:

The chemical was applied to five rats per sex (hairs removed from the trunk). During the single application of 1 ml/kg for 24 hours, the skin was covered with plaster backed with aluminium foil.

Result: LD50 > 1.08 g/kg bw (rat); no death occured. Immediately after application the animals showed excitation for 2 hours, within 24 h difficulty of breathing occured. The general condition of the animals was reduced up to 8 d after administration of the test substance.