Registration Dossier
Registration Dossier
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EC number: 252-038-4 | CAS number: 34452-51-2
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- see attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Materials and methods
Test material
- Reference substance name:
- Potassium mercaptoacetate
- EC Number:
- 252-038-4
- EC Name:
- Potassium mercaptoacetate
- Cas Number:
- 34452-51-2
- Molecular formula:
- C2H4O2S.K
- IUPAC Name:
- potassium sulfanylacetate
Constituent 1
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 18 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- clinical signs
- mortality
- Remarks on result:
- other: corrected for molecular weight differences
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 89 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- clinical signs
- mortality
- Remarks on result:
- other: corrected for molecular weight differences
Maternal abnormalities
- Key result
- Abnormalities:
- no effects observed
Results (fetuses)
Effect levels (fetuses)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 89 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- corrected for molecular weight differences
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- > 89 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- corrected for molecular weight differences
Fetal abnormalities
- Key result
- Abnormalities:
- no effects observed
Overall developmental toxicity
- Key result
- Developmental effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- By analogy to ATG, KTG is considered to be non-teratogenic to rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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