Zirconium acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Well documented, scientifically sound study with methods similar to OECD 401 with the following deviations: The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1950

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Zirconium acetate

EC Number:

231-492-7

EC Name:

Zirconium acetate

Cas Number:

7585-20-8

Molecular formula:

C2H4O2.xZr

IUPAC Name:

λ²-zirconium(2+) diacetate

Details on test material:

- Name of test material (as cited in study report): zirconyl acetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: adult rats
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

50% aqueous solutions were used.

Doses:

Single dose, no more data

No. of animals per sex per dose:

24 rats in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days

Statistics:

The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

4 100 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 660 mg/kg bw

Based on:

element

Remarks:

Zr

Mortality:

The rats showed a progressive depression and decrease in activity until death occurred.
No sex differences were noted, and the LD50 value was therefore derived from the combined data on both sexes.
The time of death varied from a few hours to a few days after administration. Few deaths however occurred later than 5 days after administration.

Clinical signs:

other: No characteristic physiologic changes were observed.

Gross pathology:

No characteristic gross pathologic changes were observed.

Applicant's summary and conclusion

Conclusions:

The acute oral LD50 value in rats via oral gavage route is 4100 mg/kg bw (zirconyl acetate).