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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971.
Author:
Hathway, D. E.
Year:
1972
Bibliographic source:
London: The Chemical Society

Materials and methods

Objective of study:
metabolism
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
human

Administration / exposure

Doses / concentrations
Remarks:
Doses / Concentrations:20 mg, 40 mg

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Formation of pentaerythritol mononitrate; Ratio pentaerythritol mononitrate: pentaerythritol excreted by urine:- Dose=40mg: 3:1- Dose=40 mg: 1:1

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Formation of pentaerythritol mononitrate.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results