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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
according to guideline
other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians (EPA, 1975)
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Test type:
Water media type:
Total exposure duration:
24 h
35 mg/1 as CaCO3,
Test temperature:
21+/-1 ºC
Dissolved oxygen:
>60% of saturation
Nominal and measured concentrations:
9700000 mg/L
Details on test conditions:
Confidence interval: 7500000-12600000 g/L
48 h
Dose descriptor:
Effect conc.:
ca. 292 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
Remarks on result:
other: 0.25
Details on results:
No reported
Validity criteria fulfilled:
Not toxic
Executive summary:

Studies performed on toxicity to Daphnia magna of pentaerythritol tetranitrate at different concentrations show that caused effects are not associated to the substance, but to the high pH of the solution (>12) resulting from desensitization, which is much higher than environmental.

To determine the effect of the high pH, resulting from the desensitization process, of test materials, bioassays were performed with Daphnia magna and Pimephales promelas exposed to neutralized versus unneutralized materials.

Description of key information

LC50 values obtained from studies performed on toxicity to Daphnia magna of pentaerythritol tetranitrate at different concentrations show that the substance is not toxic. Observed mortality seems to be associated to high pH (>12), resulting from the desensitization process.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
292 mg/L

Additional information