Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians (EPA, 1975)
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Total exposure duration:
24 h
Hardness:
35 mg/1 as CaCO3,
Test temperature:
21+/-1 ºC
pH:
7.1
Dissolved oxygen:
>60% of saturation
Nominal and measured concentrations:
9700000 mg/L
Details on test conditions:
Confidence interval: 7500000-12600000 g/L
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
ca. 292 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 0.25
Details on results:
No reported
Validity criteria fulfilled:
yes
Conclusions:
Not toxic
Executive summary:

Studies performed on toxicity to Daphnia magna of pentaerythritol tetranitrate at different concentrations show that caused effects are not associated to the substance, but to the high pH of the solution (>12) resulting from desensitization, which is much higher than environmental.

To determine the effect of the high pH, resulting from the desensitization process, of test materials, bioassays were performed with Daphnia magna and Pimephales promelas exposed to neutralized versus unneutralized materials.

Description of key information

LC50 values obtained from studies performed on toxicity to Daphnia magna of pentaerythritol tetranitrate at different concentrations show that the substance is not toxic. Observed mortality seems to be associated to high pH (>12), resulting from the desensitization process.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
292 mg/L

Additional information