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EC number: 202-426-4 | CAS number: 95-51-2
Only slight symptoms of an irritating potential for respiratory organs (nasal secretion) at 4.4 mg/L (aerosol).
Märtins, T (1990)
2 -chloroaniline was tested for acute inhalation toxicity according to OECD 403 on male and female young adult wistar rats in a head/nose only apparatus for 4 h. The concentration in the test chamber was monitored throughout the experiment. Following concentration (analytical) of 2 -chloroaniline were applied as vapour: 0.371, 0.745 or 1.156 mg/L (group 2,3 and 4, respectively) and as aerosol up to the maximal attainable dose: 2.642 or 4.406 mg/L, group 5 and 6, respectively. Controls were exposed in the same way to a water/air mixture.No mortality was observed in all groups. No pathophysiological changes were evident. Signs of toxicity were only observed in Group 4 to 6 and included: tremor, face down position, reduced mortor activity and in the highest dose group serous secretion from the nose, indicating an irritating effect to the respiratory system. Therefore the LD50 value is greater than 4.406 mg/L. Based on this study o-Chloroaniline showed only slight toxic potential without mortality and should be classified as harmul if inhaled.
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