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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Method not validated

Data source

Reference
Reference Type:
publication
Title:
Environmental chemical permeation of bovine ocular lens capsule
Author:
Ismail, R et al.
Year:
1976
Bibliographic source:
Chemosphere, 2: 145-150

Materials and methods

Type of study / information:
permeation of bovine lens in vitro
Principles of method if other than guideline:
permeation of bovine lens in vitro
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Results and discussion

Any other information on results incl. tables

At an initial concentration of 0.026%, 16 and 45% permeation
was measured after 3 and 24 hours, respectively (50% meaning
equilibrium between outer and inner compartment). Aldolase and malate dehydrogenase activity were reduced by o-chloroaniline whereas glucose-6 -phosphate dehydrogenase and glutamate-pyruvate-transaminase activity were increased.

Applicant's summary and conclusion