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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable well documented publication which meets basic scientific principles, but no guideline followed

Data source

Reference
Reference Type:
publication
Title:
Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats
Author:
Valentovic, MA et al.
Year:
1992
Bibliographic source:
Toxicology, 75: 121-131

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
After i.p. injection of 1.0 or 1.25 mmoles/kg in male Fischer 344 rats (>= 4 per group),urin output, reduced kidney weight, tubular casts and accumulation of p-aminohippurate and tetraethylammonium by renal cortical slices obtained from treated animals was determined 24 hours p.a..
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-chloroaniline hydrochloride

- Analytical purity: highest purity available, no further data

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Vehicle:
physiological saline
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
see remarks on results
Frequency of treatment:
see remarks on results
Post exposure period:
see remarks on results
Doses / concentrations
Remarks:
Doses / Concentrations:
see remarks on results
Basis:

No. of animals per sex per dose:
see remarks on results
Control animals:
other: see remarks on results

Results and discussion

Details on results:
see remarks on results

Any other information on results incl. tables

After i.p. injection of 1.0 or 1.25 mmoles/kg in male
Fischer 344 rats (>= 4 per group), reduced urin output,
reduced kidney weight, tubular casts and a reduced
accumulation of p-aminohippurate and tetraethylammonium by
renal cortical slices obtained from treated animals was
observed 24 hours p.a.. Blood urea nitrogen levels were
increased significantly at both concentrations.
Morphological changes in the kidneys were minor. Hepatic
alterations were characterised by elevated plasma ALT/GTP
levels and morphological changes in the centrilobular
region.

Applicant's summary and conclusion