Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: endpoint study record was created to contribute to the overall results; Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the toxicity of substances to be assessed for biodegradability
Author:
Reynolds L, Blok J, de Morsier A, Gerike P, Wellens H, Bontinck WJ
Year:
1987
Bibliographic source:
Chemosphere 16, 2259-2277

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD 301A
Principles of method if other than guideline:
endpoint study record was created to contribute to the overall results
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroaniline
EC Number:
202-426-4
EC Name:
2-chloroaniline
Cas Number:
95-51-2
Molecular formula:
C6H6ClN
IUPAC Name:
2-chloroaniline

Test organisms

Test organisms (species):
activated sludge

Study design

Total exposure duration:
7 d

Results and discussion

Effect concentrations
Duration:
7 d
Dose descriptor:
EC50
Effect conc.:
> 27 mg/L
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Any other information on results incl. tables

endpoint study record was created to contribute to the overall results;

This study represents with an EC50 (7 d) of >27 mg o-chloroaniline/L for activated sludge the lowest detected microbial inhibition value described in the available literature.

Applicant's summary and conclusion

Executive summary:

Reynolds et al. (1987) (endpoint study record was created to contribute to the overall results);

This study represents with an EC50 (7 d) of >27 mg o-chloroaniline/L for activated sludge the lowest detected microbial inhibition value described in the available literature.