Registration Dossier

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Testing decisions of the TSCA Interagency Testing Committee for Chemicals on the Canadian Environmental Protection Act Domestic Substances List and Priority substances List: Di-tert-butylphenol, Ethyl Benzene, Brominated Flame Retardants..., and Anilines
Author:
Walker JD
Year:
1996
Bibliographic source:
Environmental Toxicology and Risk Assessment: Fourth Volume, ASTM STP 1262, La Point TW et al. (eds.) American Society for Testing and Materials
Reference Type:
other: TSCA ITC Report
Title:
unknown (secondary source (Walker 1996) doesn't state which of the ITC reports in the reference list is the one from which the fish test results were taken)
Author:
TSCA Interagency Testing Committee

Materials and methods

Principles of method if other than guideline:
Only secondary literature available; endpoint study record was created to contribute to the overall results
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroaniline
EC Number:
202-426-4
EC Name:
2-chloroaniline
Cas Number:
95-51-2
Molecular formula:
C6H6ClN
IUPAC Name:
2-chloroaniline

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Water media type:
freshwater
Total exposure duration:
105 d

Results and discussion

Effect concentrations
Duration:
105 d
Dose descriptor:
other: MATC (maximum acceptable toxicant concentration)
Effect conc.:
0.007 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.

Any other information on results incl. tables

Only secondary literature available; endpoint study record was created to contribute to the overall results:

The result reported was taken only from a secondary literature source. Taking this into account, the study record currently has to be assessed as not reliable. Unfortunately, the secondary source (Walker 1996) doesn't state which of the ITC reports in the reference list is the one from which the fish test results were taken.

This long-term result of a maximum acceptable toxicant concentration MATC of 0.0067 mg o-chloroaniline/L is about 2 orders of magnitute below the acute fish toxicity values (EC50 and EC0).

Applicant's summary and conclusion