Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-402-6 | CAS number: 106-48-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A weight of evidence approach was used to determine the genetic toxicity of 4-chlorophenol. In a non guideline but comparable to guideline Ames test (Haworth S. et al, 1983) Salmonella typhimurium strains TA1535, TA1537, TA98 and TA100 were treated with the test material 4-chlorophenol diluted in DMSO using the preincubation method of application. Five dose levels, in triplicate, both with and without metabolic activation. No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose of the test material, either with or without metabolic activation.
In a OECD 471 study (RL4, method shortly described) Salmonella typhimurium strains TA1535, TA1537, TA98 and TA100 and E.coli strain E.coli WP2 uvr A were treated with the test material diluted in DMSO using the preincubation method of application at six dose levels, in duplicate, both with and without metabolic activation. Also in this study no significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose of the test material, either with or without metabolic activation.
Short description of key information:
WoE, Haworth et al., Ames, 1983, RL2, negative
WoE, MHLW, 2000, Ames, RL4, negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available data on genotoxicity of the test substance are insufficient for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
