Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 265-069-3 | CAS number: 64741-67-9 A complex combination of hydrocarbons produced as the residual fraction from distillation of the product from a catalytic reforming process. It consists of predominantly aromatic hydrocarbons having carbon numbers predominantly in the range of C10 through C25 and boiling in the range of approximately 160°C to 400°C (320°F to 725°F). This stream is likely to contain 5 wt. % or more of 4- or 6-membered condensed ring aromatic hydrocarbons.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Near-guideline, GLP-compliant study. Adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 68553-00-4
- Cas Number:
- 68553-00-4
- IUPAC Name:
- 68553-00-4
- Reference substance name:
- Fuel oil No. 6
- IUPAC Name:
- Fuel oil No. 6
- Test material form:
- other: viscous hydrocarbon liquid
- Details on test material:
- No. 6 Heavy Fuel Oil (API 78-6 with Specific Gravity
0.99/2.7%S),Fuel oil No. 6, CAS No. 68553-00-4.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.35
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.08
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
Any other information on results incl. tables
A mean primary dermal irritation index of
0.35 out of a maximum score of 8.0 indicated that the test substance was
minimally irritating. The mean erythema score for the
intact skin was 0.25, and the mean oedema score was also 0.25.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Application of the material to the clipped skin of rabbits under occlusive patch for 24 hrs did not result in significant dermal irritation.
- Executive summary:
The material was applied to the clipped skin of three male and three female New Zealand White rabbits for 24 hours. 0.5 mL of test substance was applied to both abraded and non-abraded skin areas and covering with a closed patch. The animals were monitored over 72 hours post exposure and scored according to the Draize scale. Significant irritation was not observed following treatment.
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