Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Unpublished report
Title:
Testing for primary irritant / corrosive effect on the skin of rabbits,"
Author:
Suberg H,
Year:
1983
Bibliographic source:
Unpublished report of Bayer AG, May 30, 1983
Report Date:
1983

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
other: HC:NZW

Test system

Duration of treatment / exposure:
24 h
Observation period (in vivo):
Observations at 1, 24, 48 and 72 hours and at 7 days after instillation of the test substance. Scoring was performed according to the Draize scheme
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Results
Remarks on result:
other: No effects were noted in corneae and irises at any observation
Other effects:
Result : 1 hour after application: all three animals showed erythema (grade 1 or 2) and two of them also chemiosis (grade 1); 24 hours after application: two animals showed erythema (grade 1) All effects were completely reversible within 48 hours. No effects were noted in corneae and irises at any observation

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
slightly irritating effects on the eyes .