Registration Dossier
Registration Dossier
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EC number: 906-256-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There is no skin sensitisation data available on the multiconstituent substance, but data is available on the main components from which it can be established that the substance does not exhibit any sensitising properties. Data on individual components:
Monoethylene glycol (ethan-1,2-diol) : Kurihara et al. (1996) reported a guinea pig maximization test. Female guinea pigs were given ethylene glycol (diluted in olive oil). No skin sensitization properties were found. Diethylene glycol (2,2’-oxydiethanol): BASF (1991) reported a skin sensitization study using guinea pigs according to EU Method B.6. For intradermal induction a 5% DEG formulation in NaCl and for epidermal induction a 75% DEG formulation in water were used. A 50% DEG formulation in water was applied for challenge. No skin reactions could be observed. Triethylene glycol (2,2’-(ethylenedioxy)diethanol): No fully valid studies regarding skin sensitization are available. However, secondary sources Ballantyne and Snellings (2007), as well as US EPA (1993), found no skin-sensitizing properties (guinea pig maximization test and human patch test).
Migrated from Short description of key information:
MEG, DEG, TEG: not sensitising.
Justification for classification or non-classification
Based on the lack of sensitisation following exposure and the lack of structural alerts for this end point, classification is not warranted under the criteria of directive 67/548 and regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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