Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Toxicokinetic Assessment for S-205
Reliability:
1 (reliable without restriction)
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no data
Results from in vivo toxicology studies performed with S-205 and an analogue substance Black 400 reveal that S-205 is poorly absorbed via the gastrointestinal tract and the skin. There is evidence of systemic distribution including to the kidneys when S-205 is administered via the oral route. The kidneys may be the site of excretion. Although S-205 log Pow indicates potential for bioaccumulation, nothing was observed in the macroscopic or microscopic investigations probably due to poor absorption across biological membranes.

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