2'-anilino-6'-[ethyl(3-methylbutyl)amino]-3'-methylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: Toxicokinetic Assessment for S-205

Reliability:

1 (reliable without restriction)

Data waiving:

other justification

Justification for data waiving:

other:

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no data
Results from in vivo toxicology studies performed with S-205 and an analogue substance Black 400 reveal that S-205 is poorly absorbed via the gastrointestinal tract and the skin. There is evidence of systemic distribution including to the kidneys when S-205 is administered via the oral route. The kidneys may be the site of excretion. Although S-205 log Pow indicates potential for bioaccumulation, nothing was observed in the macroscopic or microscopic investigations probably due to poor absorption across biological membranes.