Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics
Type of information:
other: Toxicokinetic Assessment for S-205
1 (reliable without restriction)
Data waiving:
other justification
Justification for data waiving:

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Interpretation of results (migrated information): no data
Results from in vivo toxicology studies performed with S-205 and an analogue substance Black 400 reveal that S-205 is poorly absorbed via the gastrointestinal tract and the skin. There is evidence of systemic distribution including to the kidneys when S-205 is administered via the oral route. The kidneys may be the site of excretion. Although S-205 log Pow indicates potential for bioaccumulation, nothing was observed in the macroscopic or microscopic investigations probably due to poor absorption across biological membranes.