Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-428-4 | CAS number: 91079-40-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 20 february 2013 to 21 february 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A well documented GLP study according to OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Peptones, casein
- EC Number:
- 293-428-4
- EC Name:
- Peptones, casein
- Cas Number:
- 91079-40-2
- Molecular formula:
- Not applicable
- IUPAC Name:
- Peptones, casein
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 6
- Details on results:
- The chromatogram of the test item gave two peaks. With the calibration function log K versus log Pow, the corresponding log Pows of both peaks were determined with:
Peak Mean Area [mAU*min]1 Rel. Area% Mean Retention Time [min] Log Pow ± Stand. Dev
1 7.4157 27.39 1.524 Not evaluable*
2 19.5316 72.53 1.712 -0.581 ± 0.023
(mAU = milli absorbance units
*Because peak 1 has a retention time lower than thiourea, no log k and log Pow is calculable).
These values are the means ± standard deviations of three independent determinations. Both peaks lie within the dead time of the method and not within the range of log Pows of the reference items. Therefore, the corresponding log Pows should be stated as < 0.3 for peaks 1 and 2.
lt is thus concluded that the test item peptone casein has a log Pow of < 0.3.
Applicant's summary and conclusion
- Conclusions:
- A log Pow < 0.3 was stated in a study using HPLC method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
