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EC number: 201-201-8
CAS number: 79-38-9
Basing on the physico-chemical properties and the environmental fate assessments of the molecule, the hydrolitic degradation of CTFE is neither measurable nor expected.
CTFE was assessed both for its physico-chemical properties and for
its environmental fate. On the grounds of these assessments, the
hydrolytic degradation of CTFE is neither measurable nor expected. In
fact the substance is a gas at ambient conditions with a strong tendency
to partition almost exclusively into the atmosphere.
According to section 2 of REACh Annex XI, testing for hydrolysis
may be omitted since it is technically not possible to conduct the study
on a volatile gas. Moreover, the Guidance on Information Requirements
and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance,
Appendix R.7.1-4 indicates that substances with a Henry's Law constant
of around 1 hPa m3/mole rapidly volatilise from water. The
Henry’s Law constant of CTFE was calculated to be 31.500 Pa m3/mol
(HENRYWIN v3.20, EPI Suite v4.0), suggesting that the substance is
expected to rapidly volatilise from water to the air.
In any case, although no partition into water is expected, the
tendency to hydrolyze has been however assessed basing on the chemical
structure of CTFE molecule.
This does not contain any functional groups associated with
hydrolysis properties at relevant environmental conditions.
Particularly, the carbon-fluorine bond is the strongest bond in organic
chemistry (O'Hagan, 2008). Substitution of hydrogen atoms with fluorine
results in increased bond strengths for both carbon-fluorine and
adjacent carbon-carbon bonds over the corresponding hydrocarbon and
would increase the resistance to hydrolysis (Lemal, 2003). Therefore,
based on this qualitative structure-activity relationship, it can be
concluded that hydrolysis is not a relevant degradation mechanism for
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