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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Summary of the primary cutaneous irritation of 56 chemicals in the rabbit using three different procedures

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the cutaneous-irritation potential of 56 compounds
Author:
Guillot JP, Gonnet JF, Clement C, Caillard L & Truhaut R
Year:
1982
Bibliographic source:
Food and Chemical Toxicology Volume 20, Issue 5, 1982, Pages 563–572

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
other: method published by the French authorities for the testing of cosmetics and toiletries (Journal Officiel 21 April 1973, p. 3862; 5 June 1973, p. 3953
Qualifier:
according to guideline
Guideline:
other: Association Française de Normalisation (AFNOR)
Principles of method if other than guideline:
The primary cutaneous irritation of 56 chemicals was tested in the rabbit using three different procedures. The three protocols selected for the tests were the method published by the French authorities for the testing of cosmetics and toiletries (Journal Officiel 21 April 1973, p. 3862; ibid 5 June 1973, p. 3953) and the methods proposed for the testing of chemicals by the Association Française de Normalisation (AFNOR) and, in 1979, by the Organisation for Economic Co-operation and Development. The results of the three sets of tests were compared and the effects of differences in procedure and numbers of animals were studied, together with the possible relation between irritancy and the pH of the test material.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium nitrate
EC Number:
236-751-8
EC Name:
Aluminium nitrate
Cas Number:
13473-90-0
Molecular formula:
Al.3HNO3
IUPAC Name:
aluminum trinitrate
Test material form:
other: white crystals
Details on test material:
The test material was ground to a powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Roucher SA
- Weight at study initiation: 2.5 kg

Test system

Type of coverage:
other: occluded or semi-occluded (OECD)
Preparation of test site:
clipped
Vehicle:
water
Remarks:
: moistened
Controls:
no
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 hours (OECD, AFNOR)
23 hours (French Cosmetic guideline)
Observation period:
1-48 hours (French Cosmetic method)
To Day 14 (AFNOR, OECD)
Number of animals:
3 or 6 (males)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Score:
0.35
Max. score:
8
Reversibility:
fully reversible
Remarks on result:
other: OECD Guideline
Irritation parameter:
overall irritation score
Basis:
mean
Score:
0.54
Max. score:
8
Reversibility:
fully reversible
Remarks on result:
other: French Cosmetic Protocl
Irritation parameter:
overall irritation score
Basis:
mean
Score:
0.36
Max. score:
8
Reversibility:
fully reversible
Remarks on result:
other: ANFOR protocol
Irritant / corrosive response data:
The authors state that the test substance was not irritating when tested according to the OECD protocol. A primary cutaneous irritation index of 0.35 was achieved. The maximum possible score was 8.0. In addition the test substance was also tested according to a protocol for cosmetics which led to a primary cutaneous irritation index of 0.54 (slightly irritant) and according to the AFNOR protocol which led to a primary cutaneous irritation of 0.36 (not irritating).
Other effects:
Not reported

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study indicate that aluminium nitrate is a slight skin irritant.
Executive summary:

The skin irritation potential of aluminium nitrate was investigated in the rabbit using three different protocols. The authors state that the test substance was not irritating when tested according to the OECD protocol. A primary cutaneous irritation index of 0.35 was achieved. The maximum possible score was 8.0. In addition the test substance was also tested according to a protocol for cosmetics which led to a primary cutaneous irritation index of 0.54 (slightly irritant) and according to the AFNOR protocol which led to a primary cutaneous irritation of 0.36 (not irritating).