Registration Dossier
Registration Dossier
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EC number: 909-709-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity data available on the reaction mass of cerium dioxide and zirconium dioxide and its constituents are shown in the table below:
Endpoints |
Reaction mass |
Cerium dioxide (nanometric) |
Cerium dioxide (micrometric) |
Zirconium dioxide |
Acute toxicity to fish |
96h-LL50 (O. mykiss) > 100 mg/L |
No data |
96h-LL50 (B. rerio) > 100 mg/L |
96h-LL50 (B. rerio) > 100 mg/L |
Chronic toxicity to fish |
Waived as scientifically unjustified |
|||
Acute toxicity to daphnids |
48h-EL50 (D. magna) > 100 mg/L |
48h-EL50 (D. magna) > 100 mg/L 48h-EC50 (D. magna) > 100% saturated solution of cerium dioxide 48h-EC50 (D. magna) > 1000 mg/L 24h-LC50 (T. platyurus) > 5000 mg/L 96h-LC50 (D. magna) > 10 mg/L |
48h-EL50 (D. magna) > 100 mg/L 48h-EC50 (D. magna) > 100% saturated solution of cerium dioxide 48h-NOEC (D. magna) > 1000 mg/L |
48h-EL50 (D. magna) > 100 mg/L |
Chronic toxicity to daphnids |
No data |
21d-NOEC (D. magna) < 18 mg/L to 56 mg/L (effects could be linked to food deprivation due to complexation of algal cells with the nanoparticles) |
22d-NOELR (D. magna) >= 100 mg/L 21d-NOEC (D. magna) >= 100 mg/L (mortality) and 32 mg/L (reproduction) |
No data |
Algal toxicity |
72h-EL50 (S. subspicatus) > 100 mg/L (observed effects concurrent with phosphate depletion, secondary effect) |
72h-NOEC (P. subcapitata) = 3.2 mg/L (no exclusion that clustering/sedimentation and phosphate deprivation are responsible for / contributed to the observed effects) |
72h-EL50 (S. subspicatus) > 100 mg/L (observed effects concurrent with phosphate depletion, secondary effect) 72h-NOEC (P. subcapitata) > 1000 mg/L |
Read across from studies with zirconium dichloride oxide and zirconium basic carbonate, indicating that observed effects are concurrent with phosphate depletion, secondary effect) |
Toxicity to micro-organisms |
No data |
3h-EC50 (activated sludge) > 1000 mg/L |
3h-EC50 (activated sludge) > 1000 mg/L |
No data |
These data clearly show that the reaction mass and its constituents present highly similar properties in terms of aquatic ecotoxicity, supporting the relevance of potential read across from data on its constituents when data on the reaction mass are not available. In the case of chronic toxicity to fish and daphnids, and toxicity to microorganisms, where no data are available for the reaction mass, it can be concluded that no adverse effects are to be expected from the reaction mass, similarly as for its constituent cerium dioxide.
Additional information
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