Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single 24 hours application of 0.1 mg dry technical grade chemical to one eye of each of 6 rabbits.
3 additional rabbits had the chemical washed out after a 20 second exposure.
GLP compliance:
yes
Remarks:
no data available

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Mononitroso-RDX
- Molecular formula (if other than submission substance): C3H6N6O5
- Molecular weight (if other than submission substance): 206
- Substance type: organic
- Physical state: powder
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available.

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mg dry techical grade.

VEHICLE
No data
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
9 rabbits
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes on three rabbits
- Time after start of exposure: 20 second

SCORING SYSTEM
No data

TOOL USED TO ASSESS SCORE
No data

Results and discussion

Any other information on results incl. tables

Mononitroso-RDX did not cause irritation to the eyes of rabbits under either unwashed or washed conditions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Irritation to human eyes is not expected from an accidental exposure.