Registration Dossier
Registration Dossier
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EC number: 204-500-1 | CAS number: 121-82-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Single 24 hours application of 0.1 mg dry technical grade chemical to one eye of each of 6 rabbits.
3 additional rabbits had the chemical washed out after a 20 second exposure. - GLP compliance:
- yes
- Remarks:
- no data available
Test material
- Reference substance name:
- Mononitroso-RDX
- IUPAC Name:
- Mononitroso-RDX
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Mononitroso-RDX
- Molecular formula (if other than submission substance): C3H6N6O5
- Molecular weight (if other than submission substance): 206
- Substance type: organic
- Physical state: powder
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available.
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mg dry techical grade.
VEHICLE
No data - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 9 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes on three rabbits
- Time after start of exposure: 20 second
SCORING SYSTEM
No data
TOOL USED TO ASSESS SCORE
No data
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Mononitroso-RDX did not cause irritation to the eyes of rabbits under either unwashed or washed conditions.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Irritation to human eyes is not expected from an accidental exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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