Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single 24 hours application to intact and abraded skin.
Dry technical grade chemical, 0.5 mg applied to each of 6 rabbits.
Occlusive covering.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Mononitroso-RDX
- Molecular formula (if other than submission substance): C3H6N6O5
- Molecular weight (if other than submission substance): 206
- Substance type: organic
- Physical state: powder
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No data available.

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mg.

VEHICLE
No data
Duration of treatment / exposure:
24 hours
Observation period:
No data available.
Number of animals:
6 rabbits.
Details on study design:
No data available.

Results and discussion

In vivo

Other effects:
No data available.

Any other information on results incl. tables

Mononitroso-RDX did not cause any irritation of the intact or abraded skin.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Mononitroso-RDX exhibits no potential for acute skin irritation and should be considered a nonirritating skin material.