Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-846-0 | CAS number: 111-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Excretion and Metabolism of Triethylene Glycol
- Author:
- McKennis, H. et al.
- Year:
- 1 961
- Bibliographic source:
- International Journal of Toxicology 25 (2), 121 - 138
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Administration of C14-triethyleneglycol to the rat.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Details on test material:
- - Name of test material (as cited in study report): triethylene glycol
- Analytical purity: 99.9%
- Locations of the label (if radiolabelling): randomly labeled 14C-triethylene glycol
- Specific activity (if radiolabelling): 5.13 µc/mg
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Albimno Farms, Red Bank, New Jersey, USA
- Metabolism cages: yes
- Diet: ad libitum; during study no food was allowed
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
Doses / concentrations
- Remarks:
- Doses / Concentrations:
125, 140, 250 and 600 mg/kg bw
- No. of animals per sex per dose / concentration:
- 2
- Control animals:
- yes
Results and discussion
Main ADME resultsopen allclose all
- Type:
- other: excretion (24 h)
- Results:
- 66% of dose recovered in urine chloroform extracts (125 mg/kg bw group)
- Type:
- other: excretion (24 h)
- Results:
- 65% of dose recovered in urine chloroform extracts (140 mg/kg bw group)
- Type:
- other: excretion (24 h)
- Results:
- 38% of dose recovered in urine chloroform extracts (250 mg/kg bw group)
- Type:
- other: excretion (24 h)
- Results:
- 56% of dose recovered in urine chloroform extracts as hydroxyacid (250 mg/kg bw group)
- Type:
- other: excretion (24 h)
- Results:
- 27% of dose recovered in urine chloroform extracts (600 mg/kg bw group)
- Type:
- other: excretion (24 h)
- Results:
- 40% of dose recovered in urine chloroform extracts as hydroxyacid (600 mg/kg bw group)
- Type:
- other: excretion (5 days)
- Results:
- 91-98% of dose recovered (14C elimination)
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Following administration of 14C-triethyleneglycol to the rat, 86-94% of the radioactivity was recovered in the urine in the subsequent 5-day period. The total excretion by way of the urine and faeces amounted to 94-97%. The expired air over a 60-h period contained approximately 1% of the administered dose.
Metabolite characterisation studies
- Details on metabolites:
- The chromatograms of chloroform extracts of urine showed no evidence of ethylene glycol or diethyleneglycol.
One oxidation product is suggested to be a monocarboxylic acid which arises by metabolic oxidation of a single terminal hydroxyl group of the parent glycol.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
High degree of elimination of triethyleneglycol and its metabolites via the urine
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.