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EC number: 203-846-0 | CAS number: 111-21-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d) ≥ 100 mg/L for activated sludge microorganisms (OECD 301C)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
The toxicity of 2,2'-[ethane-1,2-diylbis(oxy)]bisethyl diacetate (CAS 111-21-7) to microorganisms was investigated in a biodegradation study according to OECD 301C under GLP conditions (Clarke, 2012). The study was performed with a mixed population of active sewage sludge microorganisms. A toxicity control included in the biodegradation study could not be evaluated due to technical problems. Nevertheless, no inhibition of biodegradation was observed after 28 d. The test concentration from a biodegradation study which indicated that the test substance is readily biodegradable can be used to derive a NOEC for this endpoint as stated in the ECHA Guidance R.7b (ECHA, 2014). Therefore, the test item concentration of 100 mg/L can be used as NOEC value for the toxicity to activates sludge microorganisms. Thus a NOEC (28 d) of ≥ 100 mg/L resulted.
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