Registration Dossier
Registration Dossier
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EC number: 200-811-1 | CAS number: 74-79-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
No acute toxic effects were observed for the oral route up to the maximum dose of 5110 mg/kg body weight. This result shows that the toxicity of L-arginine via the oral route is extremely low.
Inhalation is not a relevant route based upon the vapour pressure and particle size (granulometry) of L-arginine.
There is sufficient weight of evidence for the absence of acute toxicity via the inhalative route. The study is not conducted in accordance with Annex XI no. 1.2. REACH and for reasons of animal welfare:
"Where sufficient weight of evidence for the presence or absence of a particuliar dangerous property is available, further testing on vertebrate animals for this property shall be omitted..."
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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