Registration Dossier
Registration Dossier
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EC number: 931-974-3 | CAS number: 1231880-35-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Observation period lasted 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
- EC Number:
- 295-101-1
- EC Name:
- Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
- Cas Number:
- 91783-23-2
- IUPAC Name:
- 91783-23-2
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 27% a.s.
- Lot/batch No.: No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- According to Guideline.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information R41 Criteria used for interpretation of results: EU
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