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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
19 Dec - 21 Dec 1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
: only basic data given, lack of details on test substance
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
2-ethylhexyl laurate
EC Number:
243-697-9
EC Name:
2-ethylhexyl laurate
Cas Number:
20292-08-4
IUPAC Name:
2-ethylhexyl laurate
Details on test material:
- Name of test material (as cited in study report): Laurate D´Ethyle Hexyle
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
No data
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3
Details on study design:
SCORING SYSTEM: Draize scoring system

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
out of all 3 animals
Time point:
other: mean over 24, 48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: reversibility not applicable
Irritation parameter:
iris score
Basis:
mean
Remarks:
out of all 3 animals
Time point:
other: mean over 24, 48 and 72 hours
Score:
0
Max. score:
2
Reversibility:
other: reversibility not applicable
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
out of all 3 animals
Time point:
other: mean over 24, 48 and 72 hours
Score:
0.33
Max. score:
3
Reversibility:
fully reversible within: 48 hours

Any other information on results incl. tables

Table 1: Results of eye irritation test

Rabbit No. / sex

Scoring [h]

Cornea

Iris

Conjunctiva

1 / m

1

0

0

1

 

24

0

0

1

 

48

0

0

0

 

72

0

0

0

 

7 days

0

0

0

Mean (24, 48, 72 h)

0

0

0.33

2 / m

1

0

0

2

 

24

0

0

1

 

48

0

0

0

 

72

0

0

0

 

7 days

0

0

0

Mean (24, 48, 72 h)

0

0

0.33

3 / m

1

0

0

2

 

24

0

0

1

 

48

0

0

0

 

72

0

0

0

 

7 days

0

0

0

Mean (24, 48, 72 h)

0

0

0.33

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified
DSD: not classified

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