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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from may 19, 2011 to september 08, 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2010-12-15
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
0.03 Pa
Remarks on result:
other: extrapolated value

Observations

The mass of sample weighed was 7.72 mg. The sample was placed in a Knudsen effusion cell with an aperture size of A = 279.9 µm. Then the cell was placed in the apparatus.

 

Temperature steps at 25, 30, 35°C and then 40° C were made. The step at 25°C was not taken into account.

After the experimentation, the test item remained a white powder. No degradation of the test item was observed.

 

Results

The vapour pressure of ETHYLVANILLINE (121-32-4) extrapolated at 25°C is 3.0 x 10-2 Pa.

Conclusions:
Vapour pressure of Ethylvanilline is 0.03 Pa at 25°C.
Executive summary:

The objective of the study (Defitraces, 2011) is to determine the vapour pressure of ETHYLVANILLINE (121-32-4) following the Commission Directive 92/69/EC – Commission Regulation (EC) No. 761/2009 - EC A4 method and OECD Guideline No. 104 (2006).

 

For determining the vapour pressure, eight methods are proposed in OECD Guideline No. 104 which can be applied in different vapour pressure ranges. For each method, the vapour pressure is determined at various temperatures.

 

The method used in this study is the Knudsen cell effusion method coupled to a micro-balance.

 

The quantity of substance leaving a cell per time unit through an aperture of known size is determined under vacuum conditions such that return of substance into the cell is negligible.

The mass of effused vapour is obtained by determining the loss of mass of the Knudsen cell.

 

As the logarithm of the vapour pressure of a pure substance is a linear function of the inverse of the temperature, the vapour pressure is determined in a limited temperature range.

 

In this study, the vapour pressure of Ethylvanilline is 0.03 Pa at 25°C.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No test substance information, no guideline, secondary litterature.
Guideline:
other: no data
GLP compliance:
not specified
Temp.:
20 °C
Vapour pressure:
< 0.001 mm Hg
Remarks on result:
other: = 0.13 Pa

No more data on results.

Endpoint:
vapour pressure
Type of information:
other: extrapolated
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No test substance information, no guideline, secondary literature, but reference handbook.
Guideline:
other: no data
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Temp.:
25 °C
Vapour pressure:
0.014 Pa

No more data on results.

Description of key information

The value retained for the vapour pressure is 0.03 Pa at 25°C (key study)

Key value for chemical safety assessment

Vapour pressure:
0.03 Pa
at the temperature of:
25 °C

Additional information

One experimental GLP study (Défitraces, 2011), OECD 104 compliant, was available and was selected as key study. The Vapour pressure value in this study is 0.03 Pa at 25°C. The study was with reliability 1 according to Klimisch scale.

Two other data issue from literature were selected as supporting studies and were with reliability 2.