Registration Dossier
Registration Dossier
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EC number: 201-228-5 | CAS number: 79-81-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study for skin sensitisation (GPMT) was performed according to GLP and OECD guideline 406, using Himalayan White spotted guinea pigs (Klecak, 1989, B-154´682). For induction, the test substance (approx. 95% vitamin-A-palmitate) has been administered intradermally (5%) and topically (100%). For challenge and rechallenge, animals were treated dermally using a 30% dilution of the test substance. The substance-treated group showed positive dermal responses upon dermal challenge (4/20 animals after 24 hours, 2/20 animals after 48 hours). Challenge controls were found negative. Upon rechallenge, none of the animals in the treatment and control groups showed dermal reactions.
Migrated from Short description of key information:
A reliable skin sensitisation GLP guideline (OECD 406) study (GPMT) was performed in guinea pigs: 4/20 animals after 24 hours, 2/20 animals after 48 hours showed dermal reaction after challenge. No skin reactions were noted at challenge in control groups and at re-challenge in treatment/control groups.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data
Migrated from Short description of key information:
no data
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
