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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
Fed. Reg. 38 No. 187, § 1500.41
Deviations:
yes
Remarks:
(occlusive treatment, duration of test substance application)
Principles of method if other than guideline:
Fed. Reg. 38 No. 187, § 1500.41
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Anisaldehyde
EC Number:
204-602-6
EC Name:
Anisaldehyde
Cas Number:
123-11-5
Molecular formula:
C8 H8 O2
IUPAC Name:
4-methoxybenzaldehyde
Details on test material:
- Name of test material (as cited in study report): Anisaldehyd
- Physical state: liquid
- Analytical purity: > 99 % (data from order sheet)

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.05 kg (male), 2.76 (male), 2.32 kg (female)
- Diet: Ssniff, Intermast

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
- Area of test site: 2.5 cm x 2.5 cm
- Amount applied: 0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
8 d
Number of animals:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

SCORING SYSTEM: according to the Draize scoring system

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24-48-72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: scaling at day 8
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24-48-72 h
Score:
0.67
Max. score:
4
Reversibility:
not fully reversible within: 48 hours
Remarks on result:
other: scaling at day 8
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24-48-72 h
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: scaling at 72 hours and day 8
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24-48-72 h
Score:
0.67
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24-48-72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24-48-72 h
Score:
0.67
Max. score:
4
Reversibility:
fully reversible within: 48 h

Any other information on results incl. tables

Exposition: 

24 h, intact skin

Animal 

Reading 

Erythema

Edema

Symptoms

1

24 h

2

2

 

2

24 h

2

0

 

3

24 h

2

2

 

1

48 h

0

0

 

2

48 h

0

0

 

3

48 h

2

0

 

1

72 h

1

0

 

2

72 h

0

0

 

3

72 h

2

0

scaling

1

8 d

0

0

scaling

2

8 d

0

0

scaling

3

8 d

1

0

scaling

1

24 - 72 h

1.00

0.67

 

2

24 - 72 h

0.67

0.00

 

3

24 - 72 h

2.00

0.67

 

Applicant's summary and conclusion