Anisaldehyde

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Version / remarks:

Fed. Reg. 38 No. 187, § 1500.41

Deviations:

yes

Remarks:

(occlusive treatment, duration of test substance application)

Principles of method if other than guideline:

Fed. Reg. 38 No. 187, § 1500.41

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Anisaldehyde

EC Number:

204-602-6

EC Name:

Anisaldehyde

Cas Number:

123-11-5

Molecular formula:

C8 H8 O2

IUPAC Name:

4-methoxybenzaldehyde

Details on test material:

- Name of test material (as cited in study report): Anisaldehyd
- Physical state: liquid
- Analytical purity: > 99 % (data from order sheet)

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.05 kg (male), 2.76 (male), 2.32 kg (female)
- Diet: Ssniff, Intermast

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

- Area of test site: 2.5 cm x 2.5 cm
- Amount applied: 0.5 mL

Duration of treatment / exposure:

24 h

Observation period:

8 d

Number of animals:

3

Details on study design:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

SCORING SYSTEM: according to the Draize scoring system

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: 24-48-72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 8 days

Remarks on result:

other: scaling at day 8

Results 2

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

other: 24-48-72 h

Score:

0.67

Max. score:

4

Reversibility:

not fully reversible within: 48 hours

Remarks on result:

other: scaling at day 8

Results 3

Irritation parameter:

erythema score

Basis:

animal #3

Time point:

other: 24-48-72 h

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: scaling at 72 hours and day 8

Results 4

Irritation parameter:

edema score

Basis:

animal #1

Time point:

other: 24-48-72 h

Score:

0.67

Max. score:

4

Reversibility:

fully reversible within: 48 h

Results 5

Irritation parameter:

edema score

Basis:

animal #2

Time point:

other: 24-48-72 h

Score:

0

Max. score:

4

Reversibility:

other: not applicable

Results 6

Irritation parameter:

edema score

Basis:

animal #3

Time point:

other: 24-48-72 h

Score:

0.67

Max. score:

4

Reversibility:

fully reversible within: 48 h

Any other information on results incl. tables

Exposition:	24 h, intact skin
Animal	Reading	Erythema	Edema	Symptoms
1	24 h	2	2
2	24 h	2	0
3	24 h	2	2
1	48 h	0	0
2	48 h	0	0
3	48 h	2	0
1	72 h	1	0
2	72 h	0	0
3	72 h	2	0	scaling
1	8 d	0	0	scaling
2	8 d	0	0	scaling
3	8 d	1	0	scaling
1	24 - 72 h	1.00	0.67
2	24 - 72 h	0.67	0.00
3	24 - 72 h	2.00	0.67