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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study report with limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
Determination of dermal LD50 of test substance in rabbits
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Anisaldehyde
EC Number:
204-602-6
EC Name:
Anisaldehyde
Cas Number:
123-11-5
Molecular formula:
C8 H8 O2
IUPAC Name:
4-methoxybenzaldehyde
Details on test material:
- Name of test material (as cited in study report): Anisic aldehyde
- Lot/batch No.:73-1
No further details provided

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
No information given on test substance removal.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
4 animals (not further specified)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Deaths: 1/4 animals on day 1.
Clinical signs:
other: Symptomatology: none
Other findings:
Skin irritation:
Slight redness: 1/3
Moderate redness: 2/3
Edema: 2/3

Applicant's summary and conclusion