Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study report with limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Principles of method if other than guideline:
Determination of dermal LD50 of test substance in rabbits
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Anisic aldehyde
- Lot/batch No.:73-1
No further details provided

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
No information given on test substance removal.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
4 animals (not further specified)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Deaths: 1/4 animals on day 1.
Clinical signs:
Symptomatology: none
Other findings:
Skin irritation:
Slight redness: 1/3
Moderate redness: 2/3
Edema: 2/3

Applicant's summary and conclusion