Anisaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: study report with limited documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Principles of method if other than guideline:

Determination of dermal LD50 of test substance in rabbits

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Anisaldehyde

EC Number:

204-602-6

EC Name:

Anisaldehyde

Cas Number:

123-11-5

Molecular formula:

C8 H8 O2

IUPAC Name:

4-methoxybenzaldehyde

Details on test material:

- Name of test material (as cited in study report): Anisic aldehyde
- Lot/batch No.:73-1
No further details provided

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

No information given on test substance removal.

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

4 animals (not further specified)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

Deaths: 1/4 animals on day 1.

Clinical signs:

other: Symptomatology: none

Other findings:

Skin irritation:
Slight redness: 1/3
Moderate redness: 2/3
Edema: 2/3