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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-426-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Since it is likely that the substance will be absorbed and in the absence of substance-specific absorption data, the default absorption values from the REACH guidance (Chapter 8, R.8.4.2) are used for DNEL derivation, namely: 100% for inhalation, 50% for oral and 50% for dermal absorption.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
As no data are available on the toxicokinetics of the substance, relevant physical-chemical properties of the substance and data from toxicity studies indicating systemic bioavailability were considered to assess the general toxicokinetics of the substance.
Physical-chemical properties:
The substance is a yellow brown, viscous liquid with a molecular weight ranging from 520 -700 g/mol. The log Pow value lies between 1.72 and 2.20 and the solubility in water is 14.25 g/L.
Bioaccumulation:
Based on its log Pow value (below 3) the substance is unlikely to bioaccumulate with the repeated intermittent exposure patterns normally encountered in the workplace but may accumulate if exposures are continuous.
Gastrointestinal absorption:
Water-soluble substances may readily dissolve into the gastrointestinal fluids. Furthermore, the log Pow between 1.82 - 2.20 makes the substance favourable for absorption. However, the high molecular weight of the substance does not favour absorption. The mortality in the acute oral toxicity study (1 out of 6 rats dosed with 2000 mg/kg bw died) and the systemic adverse effects observed in the oral (gavage) repeated-dose toxicity study in rats (OECD422) indicate availability by the oral route. It is thus expected that the substance will be absorbed by the gastrointestinal tract.
Dermal absorption:
The log Pow between 1.82 - 2.20 and the high water solubility of the substance favour dermal absorption. On the other hand, the molecule may be too large for dermal uptake (molecular weight above 500). As the substance is a skin irritant, damage to the skin surface may enhance penetration. Further, the substance is a skin sensitizer and evidence of systemic toxicity (weight loss) occurred in the dermal studies with the substance (local lymph node assay in mice, acute dermal toxicity study in rats). Overall, these data suggest that the substance will be absorbed by the dermal route.
Respiratory absorption:
No experimental data is available concerning the respiratory hazard of the substance. The log Pow value between 1.72 - 2.20 is favourable for absorption directly across the respiratory tract epithelium by passive diffusion.As signs of systemic toxicity occurred in the oral toxicity studies with the substance, which indicates the potential for absorption following ingestion, it is likely that the substance will also be absorbed if it is inhaled.Overall, it is therefore expected that the substance will be absorbed by inhalation.
Since it is likely that the substance will be absorbed via the inhalation, oral and dermal route, and in the absence of substance-specific absorption data, the default absorption values from the REACH guidance (Chapter 8, R.8.4.2) are used for DNEL derivation, namely: 100% for inhalation, 50% for oral and 50% for dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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