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Toxicity to microorganisms

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Description of key information

To determine the toxicity of p-nonylphenol-formaldehyde-diethanolamine, Mannich base  to STP microorganisms, a GLP-compliant activated sludge respiration inhibition test was performed in accordance with OECD Guideline 209 (Toxi-Coop Zrt. 2013). The inhibitory effect of the test substance on activated sludge microorganisms respiration was tested at concentrations of 0, 10, 20, 40, 80 and 160 mg/L. The inhibition of the specific respiration rates compared to blank controls showed clear dose-related tendency with inhibitions of 7.0% at 20 mg/L, 16.1% at 40 mg/L, 35.5% at 80 mg/L and 73.8% at 160 mg/L. Based on these data, the 3-h EC50 and EC10 values are determined at 114.2 mg/L and 31.4 mg/L, respectively.

Key value for chemical safety assessment

EC50 for microorganisms:
114.2 mg/L
EC10 or NOEC for microorganisms:
31.4 mg/L

Additional information