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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient information to evaluate the substance

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Principles of method if other than guideline:
Method: other: application of 0.1 ml of the undiluted substance into the eye of each of 6 rabbits reading 24hrs, 48 hrs and 72 hours : cornea, iris,
conjunctivae
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30 °C

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no further information

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: the second eye served as control
Amount / concentration applied:
undiluted
Amount applied: 0.1 ml
Duration of treatment / exposure:
no data
Observation period (in vivo):
up to 72 hours
Number of animals or in vitro replicates:
6
Details on study design:
Comment: no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 24 hour reading
Score:
ca. 91.3
Max. score:
110
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 48 hour reading
Score:
ca. 86.3
Max. score:
110
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 72 hour reading
Score:
ca. 82.7
Max. score:
110
Reversibility:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: after 72 hour reading
Score:
ca. 91.3
Max. score:
110
Reversibility:
not reversible
Irritant / corrosive response data:
no further data
Other effects:
none reported

Any other information on results incl. tables

RS-Freetext:
Total irritation score: 91.3/110

Applicant's summary and conclusion

Executive summary:

Application of 0.1 ml undiluted testsubstance into the eyes of rabbits and observation for up to 72 hours resulted into a mean score of 97 of max 110. Reversibility is not reported (Industrial Biotest Laboratories 1969).