Registration Dossier
Registration Dossier
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EC number: 204-783-1 | CAS number: 126-33-0
Carcinogenicity
Administrative data
Description of key information
No specific carcinogenicity data are available on sulfolane, however, their simple chemical structures with no reactive groups and no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that sulfolane is not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In accordance with section 1 of REACH Annex XI, testing does not appear to be scientifically necessary since negative genotoxicity data and consideration of their simple chemical structures provide sufficient weight of evidence to conclude sulfolane is unlikely to show any significant carcinogenic activity.
Sulfolane has a low potential for carcinogenicity and therefore do not warrant classification under GHS/CLP.
Additional information
There are no carcinogenicity studies available for sulfolane. However, a consideration of the simple chemical structure, which has no reactive groups and carries no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis (Ashby and Tennant, 1988), together with the conclusion that sulfolane is not genotoxic, provide a strong case for concluding that sulfolane will not show any significant carcinogenic activity. Taking these data into account, together with the general lack of toxicity across other endpoints, it is considered that there is no justification for conducting further animal carcinogenicity studies. The above reasoning leads to the conclusion that sulfolane can be considered to have low concern for human carcinogenicity.
References
Ashby J and Tennant RW (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U. S. NCI/NTP. Mutat Res 204: 17-115.
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