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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06/01/2009 to 09/03/2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP in accordance with recognised guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
yes
Remarks:
No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

Constituent 1

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Any other information on results incl. tables

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 250°C (523.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of -1500 K is imposed upon it.

Run 5

Temperature (°C) Temperature (K) Reciprocal Temperature (K-1) Mass difference (µg) Mass difference (kg) Vapour pressure (Pa) Log10 Vp
240 513.15 0.001948748 7.06 7.060E-09 0.009801089 -2.008725678
241 514.15 0.001944958 7.38 7.380E-09 0.010245331 -1.989474017
242 515.15 0.001941182 5.89 5.890E-09 0.008176829 -2.087415084
243 516.15 0.001937421 9.03 9.030E-09 0.012535953 -1.901842628
244 517.15 0.001933675 6.91 6.910E-09 0.009592850 -2.018052331
245 518.15 0.001929943 9.42 9.420E-09 0.013077373 -1.883479476
246 519.15 0.001926226 8.71 8.710E-09 0.012091711 -1.917512224
247 520.15 0.001922522 10.13 1.013E-08 0.014063035 -1.851920933
248 521.15 0.001918833 12.56 1.256E-08 0.017436498 -1.758540739
249 522.15 0.001915158 12.72 1.272E-08 0.017658619 -1.753043267
250 523.15 0.001911498 13.27 1.327E-08 0.018422160 -1.734659456

No statistical analysis is given due to the nature of the plot.

The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressurebalance method. Extrapolationto 25°C gave avapour pressureof1.263x10-4Pawhichhas been taken as a maximum for this material.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test material has been determined to be less than 1.3 x 10-4 Pa at 25°C. The test material did not change in appearance under the conditions used in the determination.
Executive summary:

In a determination of hazardous physico-chemical properties study (Harlan project number: 0959/0225) the test material is shown to have a vapour pressure of less than 1.3 x 10 -4 Pa at 25°C.

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 Vapour Pressure of Council Regulation (EC) No 440/2008 of 30 May 2008.

 

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 250°C (523.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of -1500 K is imposed upon it.

 

The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25°C gave a vapour pressure of 1.263 x 10-4 Pa which has been taken as a maximum for this material.