Registration Dossier
Registration Dossier
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EC number: 201-853-3 | CAS number: 88-72-2
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): o-Nitrotoluene
- Analytical purity: not specified - Boiling pt.:
- 222 °C
- Atm. press.:
- 1 013 hPa
- Executive summary:
Roempp, 2009
The boiling point of 2-nitrotoluene was reported a s 222 °C at 1013 hPa.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Analytical purity: not specified
- Boiling pt.:
- 222.3 °C
- Atm. press.:
- 1 010 hPa
- Executive summary:
Booth G (Ullmann), 2009
The boiling point of 2-nitrotoluene was reported a s 222.3 °C at 1010 hPa.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Analytical purity: not specified
- Key result
- Boiling pt.:
- 220.4 °C
- Remarks on result:
- other: atmospheric pressure was not reported
- Executive summary:
Merck Index, 2006
The boiling point of 2-nitrotoluene was reported as 220.4 °C. Atmospheric pressure was not reported.
Referenceopen allclose all
atmospheric pressure was not reported
Description of key information
The individual study reports (data from handbooks or collection of data) show some deficiencies with respect to the comprehensiveness of the experimental details. Therefore, a reliability of 1 or 2 and thus adequacy as key study was not assignable for any of the individual studies. Consequently, the studies were assigned a Klimisch score of 4 (according to guidance document R.4, ‘not assignable: studies or data […] which are only listed in short abstracts or secondary literature (books, reviews, etc.)). As the individual studies report values are in a similar range, collectively, these studies can be used to conclude on this endpoint and to satisfy the information requirement.
The boiling point of 2-Nitrotoluene was determined in a series of experimental studies and found to be in the range of 220.4 - 222.3 °C:
Roempp, 2009: The boiling point of 2-nitrotoluene was reported as 222 °C at 1013 hPa.
Booth G (Ullmann), 2009: The boiling point of 2-nitrotoluene was reported as 222.3 °C at 1010 hPa.
Merck Index, 2006: The boiling point of 2-nitrotoluene was reported as 220.4 °C. Atmospheric pressure was not reported.
The reported boiling point by ROEMPP 2009 was chosen as the key value, because it was measured at normal pressure.
Key value for chemical safety assessment
- Boiling point at 101 325 Pa:
- 222 °C
Additional information
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