Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study used for notification under 67/548. Original study report not available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17H14O
IUPAC Name:
2-(benzyloxy)naphthalene
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
5
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
no mortality occured
Clinical signs:
other: Signs of toxicity related to dose levels: after application tousled fur was observed for the rest of the day. no other signs of toxicity were observed throughout the study.
Gross pathology:
no gross lessions were observed.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The limit test for oral toxicity in the rat did not show any toxic effects up to a dose of 5000 mg/kg bw.
Executive summary:

The study was conducted according to Guideline EU B.1 and was designed as a limit test.

A single dose of 5000 mg/kg bw of the substance in CMC (carboxymethyl cellulose) was administered to rats by the oral route.

After the application, the animals showed tousled fur for the rest of the day. No signs of toxicity were observed for the duration of the study.