Registration Dossier
Registration Dossier
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EC number: 405-490-3 | CAS number: 613-62-7 BENZYL-2-NAPHTHYLETHER; BETA-NAPHTHYLBENZYLETHER (BON); BNE; BON; NIPAFAX BNE; SENSLON-50; ZO-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study used for notification under 67/548. Original study report not available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(phenylmethoxy)naphthalene
- EC Number:
- 405-490-3
- EC Name:
- 2-(phenylmethoxy)naphthalene
- Cas Number:
- 613-62-7
- Molecular formula:
- C17H14O
- IUPAC Name:
- 2-(benzyloxy)naphthalene
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- no mortality occured
- Clinical signs:
- other: Signs of toxicity related to dose levels: after application tousled fur was observed for the rest of the day. no other signs of toxicity were observed throughout the study.
- Gross pathology:
- no gross lessions were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The limit test for oral toxicity in the rat did not show any toxic effects up to a dose of 5000 mg/kg bw.
- Executive summary:
The study was conducted according to Guideline EU B.1 and was designed as a limit test.
A single dose of 5000 mg/kg bw of the substance in CMC (carboxymethyl cellulose) was administered to rats by the oral route.
After the application, the animals showed tousled fur for the rest of the day. No signs of toxicity were observed for the duration of the study.
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