2-(phenylmethoxy)naphthalene

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: OECD Guideline study, compliant with GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2005

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Principles of method if other than guideline:

Cascade impactor method

GLP compliance:

yes (incl. QA statement)

Type of distribution:

counted distribution

Test material

Test material information

Constituent 1

Reference substance name:

ZO-1

IUPAC Name:

ZO-1

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Sponsor's identification: ZO-1
Desription: white powder
Batch number: 0603
Storage conditions: room temperature, in the dark

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size distribution at different passages

Particle size distribution at different passages 1

No.:

#1

Size:

> 10.2 µm

Distribution:

ca. 95.04 %

Particle size distribution at different passages 2

No.:

#2

Size:

> 0 - < 10.2 µm

Distribution:

ca. 4.96 %

Particle size distribution at different passages 3

No.:

#3

Size:

> 0 - < 5.4 µm

Distribution:

ca. 1.55 %

Any other information on results incl. tables

Screening test

The results of the sieving procedure (100µm sieve) are shown in the following table:

Mass of test material transferred to sieve (g): 15.45

Mass of test material passed through sieve (g): 12.87

Test material less than sieve aperture size (%): 83.3

Too few particles were of a size less than 10.2 µm to allow accurate assessment of mass median aerodynamic diameter.

Applicant's summary and conclusion

Conclusions:

Proportion of test material having an inhalable particle size less than 100 µm: 83.3 %.
Proportion of test material having a thoracic particle size less than 10.2 µm: 4.96 %
Proportion of test material having a respirable particle size less than 5.4 µm: 1.55 %

Executive summary:

The particle size distributio of the test substance was determined semi-quantitative using the sieve method as pretest and the cascade Impactor method.

The Particle size data acquired for the test material are shown in the following table:

Proportion of test material having an inhalable particle size less than 100 µm: 83.3 %.

Proportion of test material having a thoracic particle size less than 10.2 µm: 4.96 %

Proportion of test material having a respirable particle size less than 5.4 µm: 1.55 %