Registration Dossier
Registration Dossier
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EC number: 220-562-2 | CAS number: 2814-77-9
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.939 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 225
- Dose descriptor starting point:
- LOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 220.4 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- based on LOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- based on 28-d RDT study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation route - already included in route-to-route
- AF for other interspecies differences:
- 1
- Justification:
- Due to the properties of the substance, a serious dangerous effect is not expected and the AFs used are sufficient.
- AF for intraspecies differences:
- 5
- Justification:
- AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Reliability 1
- AF for remaining uncertainties:
- 2.5
- Justification:
- REACH guidance
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.725 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 450
- Dose descriptor starting point:
- LOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 108.7 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- LOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- based on 28-d RDT study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation route - already included in route-to-route extrapolation.
- AF for other interspecies differences:
- 1
- Justification:
- Due to the properties of the substance, a serious dangerous effect is not expected and the AFs used are sufficient.
- AF for intraspecies differences:
- 10
- Justification:
- AF for general population.
- AF for the quality of the whole database:
- 1
- Justification:
- Reliability 1
- AF for remaining uncertainties:
- 2.5
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.139 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1 800
- Dose descriptor starting point:
- LOAEL
- Value:
- 250 mg/kg bw/day
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat
- AF for intraspecies differences:
- 10
- Justification:
- gen. population
- AF for the quality of the whole database:
- 3
- Justification:
- LOAEL
- AF for remaining uncertainties:
- 2.5
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
