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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1994
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD Test Method 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
other: LD50
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sulfonyl chlorides, C10-21-alkane
EC Number:
293-741-6
EC Name:
Sulfonyl chlorides, C10-21-alkane
Cas Number:
91082-29-0
IUPAC Name:
91082-29-0
Constituent 2
Reference substance name:
C10-C20 alkane sulfonyl chlorides
IUPAC Name:
C10-C20 alkane sulfonyl chlorides

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
Total volume of vehicle was 10 mL/kg
Doses:
10000, 15000 mg/kg body weight
No. of animals per sex per dose:
Ten male rats per dose
Details on study design:
The observation period, after which animals were killed, was 14 days.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 15 000 mg/kg bw
Mortality:
No mortality occurred during the full observational period

Applicant's summary and conclusion

Conclusions:
No mortality occurred after a single administration to male Wistar rats by oral gavage up to a dose of 15000 mg/kg bodyweight.
Executive summary:

The acute oral toxicity of C10-21 alkane sulfonyl chloride was tested in male Wistar rats following the principles of the now deleted OECD Test Method 401 (Acute Oral Toxicity) with acceptable modifications. Single doses of the test substance were administered by oral gavage up to a maximum dose of 15000 mg/kg body weight. No mortility was observed at any of the administered doses. The LD50 of the test material (C10-21 alkane sulfonyl chloride) was > 15000 mg/kg bodyweight.

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