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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation
Remarks:
other: read-across from in vivo experimental test with an analogue
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Calcium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the eye irritation endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other:
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from Letter of Access experimental data (test method similar to OECD 405) on the analogue Calcium Acetate.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Calcium di(acetate)
EC Number:
200-540-9
EC Name:
Calcium di(acetate)
Cas Number:
62-54-4
IUPAC Name:
calcium diacetate
Details on test material:
- Name of test material (as cited in study report): Calciumacetat
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 h- 8 days
Score:
0
Max. score:
0
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24 h
Score:
0.667
Max. score:
4
Remarks on result:
other: (Involvement)
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 48 h- 72 h
Score:
0.333
Max. score:
2
Remarks on result:
other: (Involvement)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 h
Score:
2
Max. score:
2
Remarks on result:
other: (Redness)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 48 h
Score:
1.167
Max. score:
2
Remarks on result:
other: (Redness)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 72 h
Score:
0.833
Max. score:
2
Remarks on result:
other: (Redness)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 h
Score:
1.333
Max. score:
2
Remarks on result:
other: (Swelling)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 48 h
Score:
0.167
Max. score:
1
Remarks on result:
other: (Swelling)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 72 h
Score:
0.333
Max. score:
2
Remarks on result:
other: (Swelling)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 h
Score:
0.667
Max. score:
1
Remarks on result:
other: (Secretion)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 48 h- 72 h
Score:
0.167
Max. score:
1
Remarks on result:
other: (Secretion)
Other effects:
Based on the experimental results obtained with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits eyes, and applying the read-across approach, the substance Magnesium Acetate is also considered as not irritating under test conditions.

The analogue Calcium Acetate, which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is - 1.38 for Calcium Acetate and -1.38 for Magnesium Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 16600 mg/L for Magnesium Acetate at 25 ºC, and
- molecular weights which are 158.166 for Calcium Acetate and 142.40 for Magnesium Acetate.

Any other information on results incl. tables

The substance Magnesium Acetate is considered as not irritating under test conditions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance Magnesium Acetate is considered as not irritating under test conditions.
Executive summary:

Based on the experimental results (reported under the endpoint record 07.03.02_01 CaAc) obtained with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits eyes, and applying the read-across approach, the substance Magnesium acetate is also considered as not irritating under test conditions.