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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: Key studies: Read-across from experimental data on the analogue substance Calcium Acetate. The oral LD50 for Magnesium Acetate for female rats is calculated to be 2422 mg/kg bw (test method according to OECD 401).
Acute inhalation toxicity: Key studies: Read-across from experimental data on the analogue substance Calcium Acetate. The (4h) LC50 in male/female rats for Magnesium Acetate is calculated to be greater than 5.04 mg/L air (test method equivalent to OECD 403).
Acute dermal toxicity: Key studies: Read-across from experimental data on the analogue Fumaric Acid. The LD 50 for Magnesium Acetate is calculated to be greater than 24530.58 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 422 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 040 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
24 530.58 mg/kg bw

Additional information

Acute oral toxicity:

Key studies:

Read-across approach from experimental results on the analogue substance Calcium Acetate: Test method was according to OECD 401.

The oral LD50 for Magnesium Acetate was 2422 mg/kg/bw (in female rats was calculated to be 1749.28 mg/kg bw, and LD50 for male rats was between 2844.94 and 4177.38 mg/kg bw).

Acute inhalation toxicity:

Key studies:

Read-across approach from experimental results on the analogue substance Calcium Acetate: Test method was similar to OECD 403.

The LC50 value for 4 hours exposition at rat (male and female) is higher than 5.6 mg/L. At this dose no mortality was observed as well as any change during the pathology observations realized at the end of the study at 14 days.

For Magnesium Acetate, the LC50 was calculated to be greater than 5.04 mg/L.

Acute dermal toxicity:

Key study:

Read-across approach from experimental results from a study similar to OECD 402 guideline on the analogue Fumaric Acid. The LD50 for Fumaric Acid is greater than 20000 mg/kg bw for rabbits.

Based on this experimental result and the molecular weights, the read-across approach is applied and the LD 50 for Magnesium Acetate is calculated to be greater than 24530.58 mg/kg bw.

Justification for classification or non-classification

Acute toxicity:

Oral: > 2000 mg/kg bw: non- classification

Dermal: LC50 > 2000 mg/kg bw: non- classification

Inhalation: LC50 > 5 mg/L: non-classification