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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian cell study: DNA damage and/or repair
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Sodium Acetate which shares the same functional group with Calcium Acetate, also has comparable values for the relevant molecular properties for the genetic toxicity endpoint.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from published experimental data (Testicular DNA-synthesis inhibition test (DSI test)) on the analogue Sodium acetate.
GLP compliance:
no
Type of assay:
other: read-across from a Testicular DNA-synthesis inhibition test (DSI test) with an analogue

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): sodium acetate
- Molecular formula (if other than submission substance):NaC2H3O2
- Molecular weight (if other than submission substance): 82.03
- Smiles notation (if other than submission substance):[Na+].[O-]C(C)=O
- InChl (if other than submission substance):InChI=1/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Positive controls validity:
not specified
Additional information on results:
Based on published experimental data on the analogue Sodium Acetate which produced no inhibitory effect on DNA-replication in male mice treated with Sodium Acetate, and applying the read-across approach, the substance Calcium acetate is also considered as not mutagenic under test conditions.

The analogue Sodium acetate which shares the same functional group with Calcium acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value, which is -3.72 for Sodium Acetate and -1.38 for Calcium acetate,
- a high water solubility, which is 1.25 g/mL at 25 ºC for Sodium acetate and 1000 g/L at 25 ºC for Calcium acetate, and
- similar molecular weights, which are 82.0 for Sodium acetate and 158.17 for Calcium acetate.

Any other information on results incl. tables

Calcium acetate is also considered as not mutagenic in male mice.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Calcium acetate is also considered as not mutagenic in male mice.
Executive summary:

Based on published experimental data on the analogue Sodium Acetate (reported under the endpoint record 07.06.02_01 NaAc) which produced no inhibitory effect on DNA-replication in male mice treated with Sodium Acetate, and applying the read-across approach, the substance Calcium acetate is also considered as not mutagenic under test conditions.