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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Sodium Acetate which shares the same functional group with Calcium Acetate, also has comparable values for the relevant molecular properties for the genetic toxicity endpoint.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from published experimental data (method (Ames et al. 1975) similar to OECD guideline 471) on the analogue Sodium acetate.
GLP compliance:
not specified
Type of assay:
other: read-across from a bacterial reverse mutation assay with an analogue

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): sodium acetate, anhydrous
- Molecular formula (if other than submission substance):NaC2H3O2
- Molecular weight (if other than submission substance): 82.03
- Smiles notation (if other than submission substance):[Na+].[O-]C(C)=O
- InChl (if other than submission substance):InChI=1/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA 92, TA 1535, TA 100, TA 1537, TA 94, and TA 98
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
other: Maximum dose tested: 38.58 mg/plate (highest non-cytotoxic estimated dose in the experiment)
Vehicle controls validity:
valid
Positive controls validity:
not specified
Additional information on results:
Based on published experimental data on the analogue Sodium Acetate which is considered to be not mutagenic on S. typhimurium TA 92, TA 1535, TA 100, TA 1537, TA 94, and TA 98, with metabolic activation, and applying the read-across approach, the substance Calcium acetate is also considered as not mutagenic under test conditions.

The analogue Sodium acetate which shares the same functional group with Calcium acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value, which is -3.72 for Sodium Acetate and -1.38 for Calcium acetate,
- a high water solubility, which is 1.25 g/mL at 25 ºC for Sodium acetate and 1000 g/L at 25 ºC for Calcium acetate, and
- similar molecular weights, which are 82.0 for Sodium acetate and 158.17 for Calcium acetate.
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

The substance Calcium Acetate is also considered as not mutagenic on S.typhimurium TA 92, TA 1535, TA 100, TA 1537, TA 94, and TA 98, with metabolic activation.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation

The substance Calcium Acetate is also considered as not mutagenic on S.typhimurium TA 92, TA 1535, TA 100, TA 1537, TA 94, and TA 98, with metabolic activation.
Executive summary:

Based on published experimental data on the analogue Sodium acetate (repoted under endpoint record 07.06.01_01 NaAc) which is considered to be not mutagenic on S. typhimurium TA 92, TA 1535, TA 100, TA 1537, TA 94, and TA 98, with metabolic activation, and applying the read-across approach, the substance Calcium acetate is also considered as not mutagenic under test conditions.